Remdesivir for COVID-19: FDA approved but still unproven

The United States has become the epicenter of the world in the ever increasing pandemic of COVID-19. While public health prevention strategies of social distancing, crowd avoidance, masking and frequent hand washing are of proven benefit, effective drug therapies for treatment are sparse. Not surprisingly, remdesivir has attracted worldwide attention, first receiving an Emergency Use Authorization (EUA) from the U.S. Food and Drug Administration (FDA) and especially with U.S. President Donald Trump taking the drug for COVID-19 earlier this month. Last week, the World Health Organization (WHO) published the largest randomized trial showing no benefit on reducing hospital stays or mortality. Nonetheless, remdesivir has received approval from the FDA for standard of care use for patients who are hospitalized.