Today, most methods to determine the proteins inside a cell rely on a crude census—scientists usually grind a large group of cells up before characterizing their genetic material. But just as a population of 100 single people differs in many ways from a population of 20 five-person households, this kind of description fails to capture information about how proteins are interacting and clumping together into functional groups.
source https://www.lifetechnology.com/blogs/life-technology-science-news/meet-the-protein-neighbors-new-method-lets-researchers-detect-proteins-in-close-proximity-in-single-cells
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