Human life hinges on the ability of our cells to cram six feet of DNA into a 10-micron nucleus—equivalent to fitting a mile of string inside one green pea. But stuffing genes into cramped quarters is only half the battle. The DNA must also remain organized, carefully coiled into loops that ensure the information remains readily accessible and not a tangled mess.
source https://phys.org/news/2021-09-linker-histones-tune-length-chromosomes.html